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Centrosome-related Service for Cancers

Cancer Centrosome-related Service

Centrosome is the major microtubule organizing center (MTOC) of animal cells, which consists of a pair of barrel-shaped centrioles surrounded by PCM. Centrosomes serve as coordination centers in eukaryotic cells and orchestrate signal transduction, cell division, polarity and migration. The centrosome duplication is spatially and temporally synchronized with DNA duplication, and any defect or disturbance during the duplication and elongation/maturation stages results in centrosomal abnormalities. The aberrations in number, structure, position and shape of centrosome are collectively known as centrosome abnormalities, which are highly correlated with malignant tumor.

Normal and cancer cell with extra centrosomes during cell cycleNormal and cancer cell with extra centrosomes during cell cycle (Mittal K, et al., 2021)

Once the cell is in the mitotic phase, specifically at prophase, the two centrosomes migrate to the opposite poles of the cell and the mitotic spindle forms between centrosomes, facilitating cell division. Numeric amplification of centrosomes results from abnormal centriole biogenesis due to centriole overduplication and de novo assembly, or mitotic/cytokinetic failure or fusion which passively increase the centrosome copy number in a sub-population of progeny cells. It’s frequently observed in anogenital cancers, aggressive breast cancers.

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